How Influenza A Virus NS1 Deals with the Ubiquitin System to Evade Innate Immunity.
Laurie-Anne LamotteLionel TafforeauPublished in: Viruses (2021)
Ubiquitination is a post-translational modification regulating critical cellular processes such as protein degradation, trafficking and signaling pathways, including activation of the innate immune response. Therefore, viruses, and particularly influenza A virus (IAV), have evolved different mechanisms to counteract this system to perform proper infection. Among IAV proteins, the non-structural protein NS1 is shown to be one of the main virulence factors involved in these viral hijackings. NS1 is notably able to inhibit the host's antiviral response through the perturbation of ubiquitination in different ways, as discussed in this review.
Keyphrases
- immune response
- dengue virus
- protein protein
- signaling pathway
- escherichia coli
- sars cov
- pseudomonas aeruginosa
- zika virus
- small molecule
- staphylococcus aureus
- amino acid
- binding protein
- toll like receptor
- dendritic cells
- biofilm formation
- cell proliferation
- pi k akt
- aedes aegypti
- inflammatory response
- candida albicans