Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis.
Nagendra MonangiHuan XuRasheda KhanamWaqasuddin KhanSaikat DebJesmin PervinJoan T Pricenull nullStephen H KennedyAbdullah Al MahmudYuemei FanThanh Q LeAngharad CareJulio A LanderoGerald F CombsElizabeth BellingJoanne ChappellFansheng KongCriag LacherSalahuddin AhmedNabidul Haque ChowdhurySayedur RahmanFurqan KabirImran NisarAneeta HotwaniUsma MehmoodAmbreen NizarJavairia KhalidUsha DhingraArup DuttaSaid AliFahad AftabMohammed Hamad JumaMonjur RahmanBellington VwalikaPatrick MusondaTahmeed AhmedMd Munirul IslamUlla AshornKenneth MaletaMikko HallmanLaura GoodfellowJuhi K GuptaAna AlfirevicSusan MurphyLarry RandKelli K RyckmanJeffrey C MurrayRajiv BahlJames A LitchCourtney Baruch-GravettZarko AlfirevicPer AshornAbdullah BaquiJane HirstCathrine HoyoFyezah JehanLaura L Jelliffe-PawlowskiAnisur RahmanDaniel E RothSunil SazawalJeffrey S A StringerGe ZhangLouis MugliaPublished in: BMJ global health (2021)
While our study observed statistically significant associations between maternal Se concentration and PTB at some sites, this did not generalise across the entire cohort. Whether population-specific factors explain the heterogeneity of our findings warrants further investigation. Further evidence is needed to understand the biologic pathways, clinical efficacy and safety, before changes to antenatal nutritional recommendations for Se supplementation are considered.