A detrimental role of RelB in mature oligodendrocytes during experimental acute encephalomyelitis.

Angela S GuptaDebolina D BiswasLa Shardai N BrownKarli MockenhauptMichael MaroneAndrew HoskinsUlrich SiebenlistTomasz Kordula

Published in: Journal of neuroinflammation (2019)

These findings suggest that RelB fine tunes inflammation and cell death/survival during EAE. Importantly, our data points out the detrimental role RelB plays in controlling survival of mature oligodendrocytes, which could be explored as a viable option to treat MS in the future.

Keyphrases

cell death
liver failure
oxidative stress
free survival
mass spectrometry
multiple sclerosis
air pollution
respiratory failure
electronic health record
current status
aortic dissection
intensive care unit
hepatitis b virus
deep learning