Why Iron Deficiency in Acute Heart Failure Should Be Treated: A Real-World Clinical Practice Study.
Raquel López-VilellaVíctor Donoso TrenadoPablo Jover PastorIgnacio Sánchez-LázaroLuis Martínez DolzLuis Almenar BonetPublished in: Life (Basel, Switzerland) (2022)
Background. This study aims to determine whether the administration of ferric carboxymaltose (FCM) in patients with acute heart failure (AHF) and iron deficiency (ID) improves morbidity and mortality. Methods. We studied 890 consecutive patients admitted for AHF. Patients were divided into six groups according to reduced left ventricular ejection fraction (HFrEF) or preserved (HFpEF), presence of ID, and administration of FCM. Emergency visits, re-admissions, and all-cause mortality were assessed at 6 months. Results. The overall prevalence of ID was 91.2%. In the HFrEF group, no differences were found in isolated events when patients with untreated vs. treated ID were compared, while differences were found in the combined event rate ( p = 0.049). The risk calculation showed an absolute risk reduction (ARR) of 10% and relative risk reduction (RRR) of 18%. In HFpEF there was a positive trend with regard to the combined event ( p = 0.107), with an ARR of 9% and an RRR of 15%. The number of patients we needed to treat to prevent a combined event was 10.5 in HFrEF and 10.8 in HFpEF. Conclusions. FCM in AHF reduced the combined event rate of emergency visits, re-admission, and all-cause death at 6 months in HF with left ventricular ejection fraction <50%, and showed a positive trend in HFpEF.
Keyphrases
- ejection fraction
- aortic stenosis
- iron deficiency
- acute heart failure
- left ventricular
- heart failure
- emergency department
- newly diagnosed
- end stage renal disease
- public health
- clinical practice
- healthcare
- chronic kidney disease
- acute myocardial infarction
- prognostic factors
- coronary artery disease
- percutaneous coronary intervention
- atrial fibrillation
- aortic valve
- hypertrophic cardiomyopathy
- patient reported
- emergency medical