Login / Signup

The Evolution of Genetic Variability at the LRRK2 Locus.

Dylan T GuentherJordan FollettRim AmouriSamia Ben SassiFaycel HentatiMatthew J Farrer
Published in: Genes (2024)
Leucine-rich repeat kinase 2 ( LRRK2 ) c.6055G>A (p.G2019S) is a frequent cause of Parkinson's disease (PD), accounting for >30% of Tunisian Arab-Berber patients. LRRK2 is widely expressed in the immune system and its kinase activity confers a survival advantage against infection in animal models. Here, we assess haplotype variability in cis and in trans of the LRRK2 c.6055G>A mutation, define the age of the pathogenic allele, explore its relationship to the age of disease onset (AOO), and provide evidence for its positive selection.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • chronic kidney disease
  • prognostic factors
  • tyrosine kinase
  • peritoneal dialysis
  • gene expression
  • copy number
  • patient reported