Associations of genetic risk and smoking with incident chronic obstructive pulmonary disease.

Pei-Dong ZhangXi-Ru ZhangAo ZhangZhi-Hao LiDan LiuYu-Jie ZhangChen Mao

Published in: The European respiratory journal (2021)

PRS constructed from millions of variants below genome-wide significance showed significant associations with incident COPD. Participants with a high genetic risk may be more susceptible to developing COPD when exposed to smoking.

Keyphrases

chronic obstructive pulmonary disease
genome wide
copy number
lung function
cardiovascular disease
dna methylation
smoking cessation
type diabetes
cystic fibrosis