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CD45-Directed CAR-T Cells with CD45 Knockout Efficiently Kill Myeloid Leukemia and Lymphoma Cells In Vitro Even after Extended Culture.

Maraike HarfmannTanja SchröderDawid GłówMaximilian JungAlmut UhdeNicolaus KrögerStefan HornKristoffer RieckenBoris FehseFrancis A Ayuk
Published in: Cancers (2024)
/CD45CAR-T cells might, for example, be useful as part of conditioning regimens prior to stem cell transplantation.
Keyphrases
  • stem cell transplantation
  • induced apoptosis
  • cell cycle arrest
  • high dose
  • acute myeloid leukemia
  • nk cells
  • endoplasmic reticulum stress
  • dendritic cells
  • signaling pathway
  • oxidative stress
  • cell proliferation
  • pi k akt