The role of sex genotype in paediatric CNS tumour incidence and survival.

Wai Cheong SoonEdward GoacherSandeep SolankiJosie HayesMelpo KapetanstratakiSusan PictonPaul Dominic ChumasRyan Koshy Mathew

Published in: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery (2021)

Interrogating population-based registries such as SEER minimises bias and provides credible data. Observed differences in incidence and OS between the sexes for different paediatric CNS tumours provide useful prognostic information for clinicians. Sex genotype was a significant independent prognostic factor in ependymomas and germinomas. Further investigation of possible epigenetic and hormonal differences may provide sex-specific vulnerabilities that may be exploitable for targeted therapy.

Keyphrases

prognostic factors
risk factors
intensive care unit
blood brain barrier
emergency department
dna methylation
gene expression
palliative care
electronic health record
big data
health information
metabolic syndrome
machine learning
artificial intelligence
insulin resistance
deep learning