Empagliflozin Induces Vascular Relaxation in Rat Coronary Artery Due to Activation of BK Channels.

Qi KongLing-Ling QianLei ZhangHuan-Huan LiuFan YangXiao-Lu ZhangChao WangXiao-Xi ZhaoKu-Lin LiRu-Xing Wang

Published in: Diabetes, metabolic syndrome and obesity : targets and therapy (2024)

Empagliflozin has a vasodilation effect on the coronary arteries in a concentration-dependent manner and can activate BK channels via the Sirt1-Nrf2 mechanism.

Keyphrases

coronary artery
oxidative stress
pulmonary artery
coronary artery disease
ischemia reperfusion injury
blood flow
aortic stenosis
ejection fraction