Congenital brain tumour in a neonate: a therapeutic challenge.
Praneetha MudeMonalisa PradhanAnuj TiwariTapas Kanti ParidaManoj Kumar NayakArun Kumar SekarSuvendu PurkaitUsha Devi RajendranPublished in: BMJ case reports (2024)
A term neonate with history of ventriculomegaly in the fetal period was diagnosed with a central nervous system tumour after radiological investigations. It was confirmed as an immature teratoma after histopathological examination. He underwent left frontal craniotomy with tumour excision. Intraoperatively, massive haemorrhage (venous bleed) occurred due to the high vascularity of the tumour and led to haemodynamic instability. A massive transfusion protocol was initiated. Despite multiple transfusions and shock management, he succumbed at 2 weeks of life. This case report highlights the importance of antenatal diagnosis and fetal MRI in prognostication and also the possible role of neoadjuvant chemotherapy in reducing tumour vascularity and, hence, bleeding.
Keyphrases
- neoadjuvant chemotherapy
- case report
- magnetic resonance imaging
- pregnant women
- lymph node
- locally advanced
- functional connectivity
- cardiac surgery
- sentinel lymph node
- atrial fibrillation
- squamous cell carcinoma
- white matter
- preterm infants
- resting state
- magnetic resonance
- early stage
- contrast enhanced
- working memory
- acute kidney injury
- multiple sclerosis
- preterm birth
- sickle cell disease
- blood brain barrier
- rectal cancer