Tubulovascular protection from protease-activated receptor-1 depletion during AKI-to-CKD transition.
Sarah W Y LokWai Han YiuYixin ZouRui XueHongyu LiJingyuan MaJiaoyi ChenLoretta Y Y ChanKar Neng LaiSydney Chi-Wai TangPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2023)
Our findings elucidate a detrimental role of PAR-1 in vascular dysfunction and profibrotic responses upon tissue injury during AKI-to-CKD transition and provide an attractive therapeutic strategy for post-injury repair in AKI.