Multisystem Inflammatory Syndrome Following SARS-CoV-2 Infection in Children: One Year after the Onset of the Pandemic in a High-Incidence Area.
Marianna FabiEmanuele FiliceCarlotta BiagiLaura AndreozziDaniela PalleriBianca Elisa MattesiniAlessia RizzelloLiliana GabrielliChiara GhizziDaniela Di LucaFabio CaramelliAlessandro De FantiMarcello LanariPublished in: Viruses (2021)
SARS-CoV-2 infection in children can trigger cardiovascular manifestations potentially requiring an intensive treatment and defining a new entity named Multisystem Inflammatory Syndrome in Children (MIS-C), whose features partially overlap with Kawasaki Disease (KD). A cross-sectional study including all diagnoses of MIS-C and KD from April 2020 to May 2021 in our metropolitan area was conducted evaluating clinical, laboratory (including immunological response, cytokines, and markers of myocardial damage), and cardiac (coronary and non-coronary) features at onset of the diseases. Evolution of ventricular dysfunction, valve regurgitations, and coronary lesions was documented. The severity of the disease was also considered based on the need for inotropic support and ICU admission. Twenty-four MIS-C were diagnosed (14 boys, median age 82 months): 13/24 cases (54.17%) presented left ventricular dysfunction, 12/24 (50%) required inotropic support, and 10/24 (41.67%) developed coronary anomalies (CALs). All patients received steroids and IVIG at a median time of 5 days (IQR1:4, IQR3:6.5) from onset of fever and heart function normalized 6 days (IQR1: 5, IQR3: 7) after therapy, while CALs persisted in one. One patient (12.5%) required infliximab because of refractory disease and still presented CALs 18 days after therapy. During the same study period, 15 KD were diagnosed: none had ventricular dysfunction, while 7/15 (46.67%) developed CALs. Three out of 15 patients (20%) still presented CALs 46 days from onset. Compared to KD, MIS-C pts have significantly higher IL8 and similar lymphocytes subpopulations. Despite a more severe presentation and initial cardiac findings compared to KD, the myocardial injury in MIS-C has a rapid response to immunomodulatory treatment (median time 6 days), in terms of ventricular function, valve regurgitations, and troponin. Incidence of CALs is similar at onset, but it tends to regress in most of the cases of MIS-C differently than in KD where CALs persist in up to 40% in the subacute stage after treatment.
Keyphrases
- left ventricular
- aortic stenosis
- ejection fraction
- end stage renal disease
- coronary artery
- heart failure
- oxidative stress
- coronary artery disease
- mitral valve
- young adults
- chronic kidney disease
- newly diagnosed
- case report
- risk factors
- aortic valve
- cardiac resynchronization therapy
- peritoneal dialysis
- emergency department
- intensive care unit
- sars cov
- mesenchymal stem cells
- bone marrow
- physical activity
- coronavirus disease
- quantum dots
- ulcerative colitis
- acute respiratory distress syndrome
- patient reported
- percutaneous coronary intervention
- drug induced