Mineralocorticoid Receptor Blocker Prevents Mineralocorticoid Receptor-Mediated Inflammation by Modulating Transcriptional Activity of Mineralocorticoid Receptor-p65-Signal Transducer and Activator of Transcription 3 Complex.

Naoto Kuyama Satoshi Araki Koichi KaikitaNobuhiro NakanishiNaoya Nakashima Shinsuke Hanatani Yuichiro Arima Masahiro Yamamoto Taishi NakamuraEiichiro YamamotoKenichi Matsushita Kunihiko Matsui Kenichi Tsujita

Published in: Journal of the American Heart Association (2024)

Esaxerenone ameliorated postinfarct remodeling in experimental MI through its anti-inflammatory properties exerted by modulating the transcriptional activity of the MR-p65-STAT3 complex. These results suggest that the MR-p65-STAT3 complex can be a novel therapeutic target for treating MI.

Keyphrases

transcription factor
anti inflammatory
gene expression
signaling pathway
cell proliferation
oxidative stress
magnetic resonance
computed tomography
magnetic resonance imaging
heat shock
nuclear factor
toll like receptor
binding protein
angiotensin ii
angiotensin converting enzyme
heat stress