Cytogenetic aberrations in adult acute lymphoblastic leukemia-A population-based study.
Emma Bergfelt LennmyrMarie EngvallGisela BarbanyLinda FogelstrandHanna RhodinHelene HallböökPublished in: EJHaem (2021)
Cytogenetic aberrations are recognized as important prognostic factors in adult acute lymphoblastic leukemia (ALL), but studies seldom include elderly patients. From the population-based Swedish ALL Registry, we identified 728 patients aged 18-95 years, who were diagnosed with ALL 1997-2015 and had cytogenetic information. Registry data were complemented with original cytogenetic reports. BCR-ABL1 was the most recurrent aberration, with a frequency of 26%, with additional cytogenetic alterations in 64%. KTM2A rearrangement was the second most frequent aberration found in 7%. Low hypodiploidy-near triploidy and complex karyotype had negative impact, while t(1;19); TCF3-PBX1 showed positive impact on overall survival. However, after correction for age only complex karyotype remained significant.
Keyphrases
- acute lymphoblastic leukemia
- prognostic factors
- allogeneic hematopoietic stem cell transplantation
- end stage renal disease
- newly diagnosed
- ejection fraction
- copy number
- chronic kidney disease
- peritoneal dialysis
- machine learning
- emergency department
- gene expression
- healthcare
- young adults
- adverse drug
- case control