GBA variants in REM sleep behavior disorder: A multicenter study.
Lynne KrohnJennifer A RuskeyUladzislau RudakouEtienne LeveilleFarnaz AsayeshMichele Tao-Ming HuIsabelle ArnulfYves DauvilliersBirgit HöglAmbra StefaniChristelle Charley MonacaBeatriz AbrilGiuseppe PlazziElena AntelmiLuigi Ferini StrambiAnna HeidbrederBradley F BoeveAlberto J EspayValérie Cochen De CockBrit MollenhauerFriederike Sixel-DöringClaudia TrenkwalderKarel SonkaDavid KemlinkMichela FigorilliMonica PulighedduFemke DijkstraMineke ViaeneWolfgang OertelMarco ToffoliGian Luigi GigliMariarosaria ValenteJean-François GagnonAlex DesautelsJacques Y MontplaisirRonald B PostumaGuy A RouleauZiv Gan OrPublished in: Neurology (2020)
GBA variants robustly and differentially increase the risk of iRBD. The rate of conversion to neurodegeneration is also increased and may be faster among severe GBA variant carriers, although confirmation will be required in larger samples. Screening for RBD in healthy carriers of GBA variants should be studied as a potential way to identify GBA variant carriers who will develop a synucleinopathy in the future.