Outcomes of adolescent males with extracranial metastatic germ cell tumors: A report from the Malignant Germ Cell Tumor International Consortium.
Furqan ShaikhDaniel StarkAdriana FonsecaHa DangCaihong XiaMark KrailoFarzana PashankarCarlos Rodriguez-GalindoThomas A OlsonJames C NicholsonMatthew J MurrayJames F AmatrudaDeborah BillmireSara StonehamA Lindsay FrazierPublished in: Cancer (2020)
Adolescent males with metastatic germ cell tumors (GCTs) are frequently treated with regimens developed for children. In this study, a large data set of male patients with metastatic GCTs across different age groups has been built to understand the outcomes of adolescent patients in comparison with children and young adults. The results suggest that adolescent males with metastatic GCTs have worse results than children and are more similar to young adults with GCTs. Therefore, the treatment of adolescents with GCTs should resemble therapeutic approaches for young adults.
Keyphrases
- young adults
- germ cell
- childhood cancer
- squamous cell carcinoma
- small cell lung cancer
- end stage renal disease
- newly diagnosed
- chronic kidney disease
- ejection fraction
- mental health
- machine learning
- peritoneal dialysis
- internal carotid artery
- physical activity
- artificial intelligence
- glycemic control
- insulin resistance
- middle cerebral artery