Associations of per- and polyfluoroalkyl substances with uterine leiomyomata incidence and growth: a prospective ultrasound study.
Lauren Anne WiseChad M ColemanSamantha SchildrothRuth J GellerSharonda M LovettBirgit Claus HennAntonia M CalafatJulianne Cook BotelhoErica E MarshNyia NoelGanesa R WegienkaTraci N BetheaQuaker E HarmonDonna D BairdAmelia K WesselinkPublished in: Journal of exposure science & environmental epidemiology (2024)
In this prospective ultrasound study of 1158 Black females aged 23-35 years at enrollment, we conducted a mixtures analysis to account for co-pollutant confounding and interaction. MeFOSAA and PFDA concentrations were inversely associated with UL incidence, while PFNA concentrations were positively associated with UL incidence. Concentrations of most PFAS were associated with decreased UL growth. This study contributes data to the sparse literature on PFAS exposure and UL development.