Obese and overweight individuals have greater knee synovial inflammation and associated structural and cartilage compositional degeneration: data from the osteoarthritis initiative.
Thanat KanthawangJannis BoddenGabby B JosephNancy E LaneMichael NevittCharles E McCullochThomas M LinkPublished in: Skeletal radiology (2020)
Being overweight or obese was significantly associated with a greater prevalence and severity of synovial inflammation imaging biomarkers. Substantial reproducibility and high correlation with knee structural, cartilage compositional degeneration, and WOMAC pain scores validate the synovial inflammation biomarkers used in this study.
Keyphrases
- weight loss
- oxidative stress
- total knee arthroplasty
- knee osteoarthritis
- adipose tissue
- metabolic syndrome
- type diabetes
- physical activity
- bariatric surgery
- weight gain
- chronic pain
- high resolution
- rheumatoid arthritis
- extracellular matrix
- neuropathic pain
- machine learning
- spinal cord
- artificial intelligence
- mass spectrometry