Hirudin Ameliorates Renal Interstitial Fibrosis via Regulating TGF-β1/Smad and NF-κB Signaling in UUO Rat Model.

Kang YangBoya FanQingyun ZhaoYue JiPanying LiuShan GaoTong RenYitian DouMing PeiHongtao Yang

Published in: Evidence-based complementary and alternative medicine : eCAM (2020)

Hirudin improves kidney injury and suppresses inflammatory response and ECM accumulation in UUO rats; its underlying mechanism may be associated with the inhibition of TGF-β1/Smad and NF-κB signaling.

Keyphrases

transforming growth factor
signaling pathway
inflammatory response
epithelial mesenchymal transition
lps induced
pi k akt
oxidative stress
nuclear factor
lipopolysaccharide induced
extracellular matrix
immune response