Inhibiting DHN- and DOPA-melanin biosynthesis pathway increased the therapeutic value of itraconazole in Madurella mycetomatis infected Galleria mellonella.
Wilson LimMickey KoningsFlorianne ParelKimberly EadieNikolaos StrepisAhmed FahalAnnelies VerbonWendy W J van de SandePublished in: Medical mycology (2022)
Melanin protects fungi from environmental stress and antifungals. We have discovered that Madurella mycetomatis produces DHN-, pyomelanin and DOPA-melanin in vivo. Inhibiting M. mycetomatis DHN-melanin biosynthesis increases therapeutic value of the antifungal itraconazole in vivo.