Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and Indiana biobank.
Dongbing LaiSally I-Chun KuoLeah WetherillFazil AlievMichael ZhangAbreu MarcoTae-Hwi Schwantes-AnDanielle M DickMeredith W FrancisEmma C JohnsonChella KamarajanSivan KinreichSamuel KupermanJacquelyn MeyersJohn I NurnbergerYunlong LiuHoward J EdenbergBernice PorjeszArpana AgrawalTatiana ForoudMarc SchuckitMartin Henry PlaweckiKathleen K BucholzVivia V McCutcheonPublished in: Alcohol, clinical & experimental research (2023)
was negatively associated with 12-month and non-abstinent remission in COGA EA, independent of behavioral measures of AUD severity and family history of remission. The discrepant results in COGA and Indiana Biobank might reflect different ascertainment strategies: Indiana Biobank participants were older and had higher rates of liver diseases, suggesting remission due to alcohol-related health conditions that manifested in later life.