Decellularization combined with enzymatic removal of N-linked glycans and residual DNA reduces inflammatory response and improves performance of porcine xenogeneic pulmonary heart valves in an ovine in vivo model.
Robert RammTobias GoeckeKarolina TheodoridisKlaus HoefflerSamir SarikouchKatja FindeisenAnatol CiubotaruSerghei CebotariIgor TudoracheAxel HaverichAndres HilfikerPublished in: Xenotransplantation (2019)
Functional xenogeneic heart valve substitutes with a low immunologic load can be produced by decellularization combined with enzymatic removal of DNA and partial deglycosylation of dpPHV.