Notch-activated mesenchymal stromal/stem cells enhance the protective effect against acetaminophen-induced acute liver injury by activating AMPK/SIRT1 pathway.
Mengxue YuMin ZhouJiahui LiRuobin ZongYufei YanLiangyi KongQiang ZhuChangyong LiPublished in: Stem cell research & therapy (2022)
Activation of Notch2 is required for the ability of MSCs to reduce the severity of APAP-induced liver damage in mice. Our findings underscore a novel molecular insights into MSCs-mediated immunomodulation by activating Notch2/COX2/AMPK/SIRT1 pathway and thus provide a new strategy for the treatment of liver inflammatory diseases.
Keyphrases
- liver injury
- drug induced
- stem cells
- oxidative stress
- mesenchymal stem cells
- cell proliferation
- bone marrow
- signaling pathway
- skeletal muscle
- diabetic rats
- ischemia reperfusion injury
- umbilical cord
- protein kinase
- type diabetes
- high fat diet induced
- single molecule
- metabolic syndrome
- adipose tissue
- insulin resistance