Wingless-type MMTV integration site family member 5a is a key inhibitor of islet stellate cells activation.

Wei XuHouFa GengJun LiangYing LiuQian LvJie WangRui LiXiu Li WangXui Kui LiuPeter M JonesZiling Sun

Published in: Journal of diabetes investigation (2019)

Our observations revealed a potential role of Wnt5a in preventing ISC activation. The maintenance of quiescent ISCs might be a desirable outcome of therapeutic strategies for diabetes mellitus.

Keyphrases

induced apoptosis
stem cells
cell cycle arrest
cell proliferation
single cell
oxidative stress
endoplasmic reticulum stress
risk assessment