Tenofovir diphosphate levels in dried blood spots are associated with virologic failure and resistance to first-line therapy in South Africa: a case-control cohort study.
Jose R Castillo-MancillaJohnathan A EdwardsJaysingh BrijkumarMahomed-Yunus MoosaYuan ZhaoIgho OfotokunBrent A JohnsonMitchell H LeeSelvan PillayMelendhran PillayPravi MoodleyDaniel R KuritzkesHenry SunpathLane R BushmanLucas EllisonPeter L AndersonVincent C MarconiPublished in: Journal of the International AIDS Society (2021)
TFV-DP in DBS showed a stepwise association with VF and drug resistance in South African PWH. Participants having VF with resistance had mid-range concentrations of TFV-DP, which were higher than those for PWH without resistance. Future research on the clinical utility of TFV-DP concentrations in DBS to predict and prevent the development of VF and drug resistance is needed.