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Guidance on radiation dose limits for the lens of the eye: overview of the recommendations in NCRP Commentary No. 26.

Lawrence T DauerElizabeth A AinsburyJoseph DynlachtDavid G HoelBarbara E K KleinDonald MayerChristina R PrescottRaymond H ThorntonEliseo VanoGayle E WoloschakCynthia M FlanneryLee E GoldsteinNobuyuki HamadaPhung K TranMichael P GrissomEleanor A Blakely
Published in: International journal of radiation biology (2017)
Radiation-induced damage to the lens of the eye can include the loss of clarity resulting in opacification or clouding several years after exposure. The impact is highly dependent on the type of radiation, how the exposure of the lens was delivered, the genetic susceptibilities of the individual exposed, and the location of the opacity relative to the visual axis of the individual. The preponderance of epidemiological evidence suggests that lens damage could occur at lower doses than previously considered and the NCRP has determined that it is prudent to reduce the recommended annual lens of the eye occupational dose limit from an equivalent dose of 150 mSv to an absorbed dose of 50 mGy. Significant additional research is still needed in the following areas: comprehensive evaluation of the overall effects of ionizing radiation on the eye, dosimetry methodology and dose-sparing optimization techniques, additional high quality epidemiology studies, and a basic understanding of the mechanisms of cataract development.
Keyphrases
  • radiation induced
  • cataract surgery
  • oxidative stress
  • risk factors