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Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model.

Daniel PaapeCatriona T PrendergastHelen P PriceJohannes S P DoehlDeborah F Smith
Published in: Parasites & vectors (2020)
NMT is an essential gene in all parasite life-cycle stages, confirming its role as a genetically-validated target for drug development.
Keyphrases
  • life cycle
  • genome wide
  • copy number
  • genome wide identification
  • dna methylation
  • transcription factor
  • free survival
  • gene expression
  • bioinformatics analysis
  • trypanosoma cruzi