Altered intestinal antibacterial gene expression response profile in irritable bowel syndrome is linked to bacterial composition and immune activation.

Sean M P Bennet Johanna Sundin Maria K Magnusson Hans Strid Julien Tap Muriel Derrien Boris Le NevéJoël DoréHans Törnblom Magnus Simrén Lena Öhman

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)

This study demonstrates an altered antibacterial gene expression profile in IBS patients compared to HS and UC patients. While not linked to symptoms, immune activity-defined IBS clusters showed different intestinal antibacterial gene expression and distinct fecal and mucosal bacterial profiles.

Keyphrases

gene expression
irritable bowel syndrome
end stage renal disease
dna methylation
chronic kidney disease
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
depressive symptoms
patient reported