Functional heterogeneity of human skin-resident memory T cells in health and disease.
Johanna StroblMuzlifah A HaniffaPublished in: Immunological reviews (2023)
The human skin is populated by a diverse pool of memory T cells, which can act rapidly in response to pathogens and cancer antigens. Tissue-resident memory T cells (T RM ) have been implicated in range of allergic, autoimmune and inflammatory skin diseases. Clonal expansion of cells with T RM properties is also known to contribute to cutaneous T-cell lymphoma. Here, we review the heterogeneous phenotypes, transcriptional programs, and effector functions of skin T RM . We summarize recent studies on T RM formation, longevity, plasticity, and retrograde migration and contextualize the findings to skin T RM and their role in maintaining skin homeostasis and altered functions in skin disease.
Keyphrases
- soft tissue
- wound healing
- working memory
- public health
- healthcare
- patient safety
- oxidative stress
- induced apoptosis
- mental health
- transcription factor
- squamous cell carcinoma
- signaling pathway
- gene expression
- papillary thyroid
- cell death
- risk assessment
- health information
- squamous cell
- immune response
- young adults
- drug induced