Dahuang Zhechong Pills Suppress Silicosis Fibrosis Progression via p38 MAPK/TGF-β1/Smad Pathway In Vitro.

Li-Juan WuXiao-Yan He Wen-Xiang WangJie LiangYu-Die ZhangJing-Tao LiangDa-Yi Chen

Published in: Evidence-based complementary and alternative medicine : eCAM (2021)

To sum up, we conclude that DHZCP protects against SiO2-induced silicosis by reducing the persistent irritation of inflammation, regulating the p38 MAPK/TGF-β1/Smad pathway.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
oxidative stress
pulmonary fibrosis
high glucose
diabetic rats
drug induced
signaling pathway
endothelial cells