Plasmodium vivax morbidity after radical cure: A cohort study in Central Vietnam.
Thanh Vinh PhamHong Van NguyenAngel Rosas AguirreVan Van NguyenMario A ClevesXa Xuan NguyenThao Thanh NguyenDuong Thanh TranHung Xuan LeNiel HensAnna Rosanas-UrgellUmberto D AlessandroNiko SpeybroeckAnnette ErhartPublished in: PLoS medicine (2019)
A substantial number of P. vivax recurrences, mainly submicroscopic (SM) and asymptomatic, were observed after high-dose PQ treatment (5.0 mg/kg). Prior P. falciparum infection was an important risk factor for all types of vivax recurrences. Malaria elimination efforts need to address this largely undetected P. vivax transmission by simultaneously tackling the reservoir of P. falciparum and P. vivax infections.