Neural Network-Based On-Chip Spectroscopy Using a Scalable Plasmonic Encoder.
Calvin BrownArtem GoncharovZachary S BallardMason FordhamAshley ClemensYunzhe QiuYair RivensonAydogan OzcanPublished in: ACS nano (2021)
Conventional spectrometers are limited by trade-offs set by size, cost, signal-to-noise ratio (SNR), and spectral resolution. Here, we demonstrate a deep learning-based spectral reconstruction framework using a compact and low-cost on-chip sensing scheme that is not constrained by many of the design trade-offs inherent to grating-based spectroscopy. The system employs a plasmonic spectral encoder chip containing 252 different tiles of nanohole arrays fabricated using a scalable and low-cost imprint lithography method, where each tile has a specific geometry and thus a specific optical transmission spectrum. The illumination spectrum of interest directly impinges upon the plasmonic encoder, and a CMOS image sensor captures the transmitted light without any lenses, gratings, or other optical components in between, making the entire hardware highly compact, lightweight, and field-portable. A trained neural network then reconstructs the unknown spectrum using the transmitted intensity information from the spectral encoder in a feed-forward and noniterative manner. Benefiting from the parallelization of neural networks, the average inference time per spectrum is ∼28 μs, which is much faster compared to other computational spectroscopy approaches. When blindly tested on 14 648 unseen spectra with varying complexity, our deep-learning based system identified 96.86% of the spectral peaks with an average peak localization error, bandwidth error, and height error of 0.19 nm, 0.18 nm, and 7.60%, respectively. This system is also highly tolerant to fabrication defects that may arise during the imprint lithography process, which further makes it ideal for applications that demand cost-effective, field-portable, and sensitive high-resolution spectroscopy tools.
Keyphrases
- low cost
- neural network
- high resolution
- single molecule
- deep learning
- optical coherence tomography
- dual energy
- high throughput
- circulating tumor cells
- high speed
- machine learning
- mass spectrometry
- photodynamic therapy
- body mass index
- solid state
- single cell
- healthcare
- computed tomography
- air pollution
- high intensity
- tandem mass spectrometry
- visible light
- energy transfer
- health information
- body composition
- density functional theory