CM from intact hAM: an easily obtained product with relevant implications for translation in regenerative medicine.
Antonietta Rosa SiliniAndrea PapaitAnna CargnoniElsa VertuaPietro RomelePatrizia Bonassi SignoroniMarta MagattiSilvia De MunariAlice MasserdottiAnna PasottiSara Rota NodariGiorgio PaganiMario BignardiOrnella ParoliniPublished in: Stem cell research & therapy (2021)
The results presented herein support the possibility to produce secretome from intact hAM and open the prospect to highly improve the scalability of the GMP production process while reducing the costs and time related to the process of cell isolation and expansion. Moreover, the possibility of having a lyophilized secretome that maintains its original properties would allow for a ready-to-use product with easier handling, shipping and storage. The use of a lyophilized product will also facilitate clinicians by permitting customized reconstitution volumes and methods according to the most suitable formula required by the clinical application.