Wnt/β-Catenin Signaling Plays a Protective Role in the Mdr2 Knockout Murine Model of Cholestatic Liver Disease.

Tirthadipa Pradhan-SunddKaris KosarHarvinder SaggiRong ZhangRavi VatsPamela CornuetSydney GreenSucha SinghGang ZengPrithu SunddKari Nejak-Bowen

Published in: Hepatology (Baltimore, Md.) (2019)

The resulting imbalance between ongoing injury and restitution led to worsening of the Mdr2 KO phenotype, suggesting caution in targeting β-catenin globally for all cholestatic conditions.

Keyphrases

liver injury
multidrug resistant
drug induced
liver fibrosis
cell proliferation
stem cells
epithelial mesenchymal transition
cancer therapy
signaling pathway
drug delivery