Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer.

Koji MatsuoKazuhiro TanabeMasaru HayashiMasae IkedaMiwa YasakaHiroko MachidaMasako ShidaKenji SatoHiroshi YoshidaTakeshi Hirasawa Tadashi Imanishi Mikio Mikami

Published in: Cancers (2020)

Comprehensive serum glycopeptide spectra analysis (CSGSA) evaluates >10,000 serum glycopeptides and identifies unique glycopeptide peaks and patterns via supervised orthogonal partial least-squares discriminant modeling. CSGSA was more accurate than cancer antigen 125 (CA125) or human epididymis protein 4 (HE4) for detecting early stage epithelial ovarian cancer. Combined CSGSA, CA125, and HE4 had improved diagnostic performance. Thus, CSGSA may be a useful screening tool for detecting early stage epithelial ovarian cancer.

Keyphrases

early stage
endothelial cells
machine learning
high resolution
squamous cell carcinoma
density functional theory
protein kinase
protein protein
sensitive detection
quantum dots