Comparison of short-term and long-term neoadjuvant hormone therapy prior to radical prostatectomy: a systematic review and meta-analysis.
Satoshi KatayamaKeiichiro MoriBenjamin PradereHadi MostafaeiVictor M SchuettfortFahad QuhalReza Sari MotlaghEkaterina LaukhtinaNico C GrossmannPawel RajwaAbdulmajeed AydhFrederik KönigRomain MathieuPeter NyiradyPierre I KarakiewiczYasutomo NasuShahrokh F ShariatPublished in: Scandinavian journal of urology (2022)
Long-term neoadjuvant ADT was associated with more favorable pathologic outcomes, but whether these findings translate into favorable survival outcomes still remains unproven due to very limited evidence. Since there are no reliable survival data, long-term neoadjuvant ADT before RP should not be used in clinical practice until more robust evidence arises from ongoing trials.
Keyphrases
- locally advanced
- rectal cancer
- radical prostatectomy
- prostate cancer
- lymph node
- clinical practice
- neoadjuvant chemotherapy
- squamous cell carcinoma
- radiation therapy
- stem cells
- metabolic syndrome
- type diabetes
- insulin resistance
- skeletal muscle
- bone marrow
- weight loss
- data analysis
- glycemic control
- clinical evaluation