Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases.

Per Kristian EideLars Magnus ValnesErika Kristina LindstrømKent-Andre MardalGeir Ringstad

Published in: Fluids and barriers of the CNS (2021)

The present observations provide in vivo quantitative evidence for substantial variation in direction and magnitude of CSF flow, with re-direction of aqueductal flow in communicating hydrocephalus, and significant extra-cranial CSF production. The grading of ventricular reflux of tracer shows promise as a clinical useful method to assess CSF flow pattern disturbances in patients.

Keyphrases

cerebrospinal fluid
end stage renal disease
ejection fraction
heart failure
newly diagnosed
prognostic factors
machine learning
positron emission tomography
artificial intelligence
patient reported