Blood Transcriptomes of SARS-CoV-2-Infected Kidney Transplant Recipients Associated with Immune Insufficiency Proportionate to Severity.

Zeguo SunZhongyang Zhang Khadija BanuYorg Al AzziAnand ReghuvaranSamuel FredericksMarina PlanouteneSusan HartzellYesl KimJohn PellGregory TietjenWilliam AschSanjay Kulkarni Richard N FormicaMeenakshi RanaJonathan S MaltzmanWeijia ZhangEnver AkalinPeter S HeegerPaolo CravediMadhav C Menon

Published in: Journal of the American Society of Nephrology : JASN (2022)

The blood transcriptome of KTRs affected by COVID-19 shows decreases in T cell and adaptive immune activation pathways during acute disease that, despite reduced immunosuppressant use, associate with severity. These pathways show recovery after acute illness.

Keyphrases

sars cov
single cell
respiratory syndrome coronavirus
coronavirus disease
liver failure
gene expression
rna seq
respiratory failure
intensive care unit