Comparison of Effect on Sicca Symptoms of Anticentromere Antibody-positive Sjögren Syndrome and Primary Sjögren Syndrome Alone.

ACA+ SS is associated with more severe objective ocular sicca and more severe subjective and objective oral sicca compared to ACA-SS. The majority of ACA+ patients with SS meet AECG criteria for pSS despite negative serology for anti-Ro/La antibodies.