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T-Cell-Dominated Immune Response Resolves Protracted SARS-CoV-2 Infection in the Absence of Neutralizing Antibodies in an Immunocompromised Individual.

Till BunseNina KoerberHannah WinterstellerJochen SchneiderAlexander GrafAleksandar RadonicAndrea ThuermerMax von KleistHelmut BlumChristoph D SpinnerTanja BauerPercy A KnolleUlrike ProtzerEva C Schulte
Published in: Microorganisms (2023)
Immunocompromised individuals are at higher risk of developing protracted and severe COVID-19, and understanding individual disease courses and SARS-CoV-2 immune responses in these individuals is of the utmost importance. For more than two years, we followed an immunocompromised individual with a protracted SARS-CoV-2 infection that was eventually cleared in the absence of a humoral neutralizing SARS-CoV-2 antibody response. By conducting an in-depth examination of this individual's immune response and comparing it to a large cohort of convalescents who spontaneously cleared a SARS-CoV-2 infection, we shed light on the interplay between B- and T-cell immunity and how they interact in clearing SARS-CoV-2 infection.
Keyphrases
  • immune response
  • respiratory syndrome coronavirus
  • sars cov
  • coronavirus disease
  • dendritic cells
  • toll like receptor
  • respiratory failure
  • dengue virus
  • intensive care unit