Login / Signup

99 Tc NMR determination of the oxygen isotope content in 18 O-enriched water.

Valerii P TarasovGayana А KirakosyanKonstantin E German
Published in: Magnetic resonance in chemistry : MRC (2017)
99 Tc NMR has been suggested as an original method of evaluating the content of oxygen isotopes in oxygen-18-enriched water, a precursor for the production of radioisotope fluorine-18 used in positron emission tomography. To this end, solutions of NH4 TcO4 or NaTcO4 (up to 0.28 mol/L) with natural abundance of oxygen isotopes in virgin or recycled 18 O-enriched water have been studied by 99 Tc NMR. The method is based on 16 O/17 O/18 O intrinsic isotope effects in the 99 Tc NMR chemical shifts, and the statistical distribution of oxygen isotopes in the coordination sphere of TcO4- and makes it possible to quantify the composition of enriched water by measuring the relative intensities of the 99 Tc NMR signals of the Tc16 O4-n18 On- isotopologues. Because the oxygen exchange between TcO4- and enriched water in neutral and alkaline solutions is characterized by slow kinetics, gaseous HCl was bubbled through a solution for a few seconds to achieve the equilibrium distribution of oxygen isotopes in the Tc coordination sphere without distortion of the oxygen composition of the water. Pertechnetate ion was selected as a probe due to its high stability in solutions and the significant 99 Tc NMR shift induced by a single 16 O→18 O substitution (-0.43 ± 0.01 ppm) in TcO4- and spin coupling constant 1 J(99 Tc-17 O) (131.46 Hz) favourable for the observation of individual signals of Tc16 O4-n18 On- isotopologues.
Keyphrases