Central metabolism as a potential origin of sex differences in morphine antinociception but not induction of antinociceptive tolerance in mice.
Florian GabelVolodya HovhannisyanVirginie AndryYannick GoumonPublished in: British journal of pharmacology (2022)
These differences are attributable mainly to morphine central metabolism, which differed between males and females in pain-related CNS regions, consistent with weaker morphine antinociceptive effects in females. However, the role of morphine metabolism in antinociceptive tolerance seemed limited.