STATs signaling pathways in dendritic cells: As potential therapeutic targets?
Sepideh SohrabiJavad MasoumiBahar NaseriFarid GhorbaninezhadShiva AlipourTohid KazemiJavad Ahmadian HerisLeili Aghebati MalekiPedram BasirjafarRaziyeh ZandvakiliMohammad Amin DoustvandiBehzad BaradaranPublished in: International reviews of immunology (2023)
Dendritic cells (DCs) are professional antigen-presenting cells (APCs), including heterogenous populations with phenotypic and functional diversity that coordinate bridging innate and adaptive immunity. Signal transducer and activator of transcriptions (STAT) factors as key proteins in cytokine signaling were shown to play distinct roles in the maturation and antigen presentation of DCs and play a pivotal role in modulating immune responses mediated by DCs such as differentiation of T cells to T helper (Th) 1, Th2 or regulatory T (Treg) cells. This review sheds light on the importance of STAT transcription factors' signaling pathways in different subtypes of DCs and highlights their targeting potential usages for improving DC-based immunotherapies for patients who suffer from cancer or diverse autoimmune conditions according to the type of the STAT transcription factor and its specific activating or inhibitory agent.
Keyphrases
- dendritic cells
- immune response
- transcription factor
- signaling pathway
- induced apoptosis
- regulatory t cells
- cell cycle arrest
- pi k akt
- cell proliferation
- endoplasmic reticulum stress
- oxidative stress
- dna binding
- toll like receptor
- squamous cell carcinoma
- papillary thyroid
- epithelial mesenchymal transition
- human health
- climate change
- nuclear factor
- cell death
- young adults
- cancer therapy
- drug delivery
- genome wide identification