Beyond Basic Research: The Contribution of Cathepsin B to Cancer Development, Diagnosis and Therapy.
Andrey A Z JuniorLevy C GregoryPaul A TownsendSurinder M SoondPublished in: Expert opinion on therapeutic targets (2022)
In doing so, we detail its maturation as a diagnostic marker through describing the development of CtsB-specific Activity-Based Probes, the rapid evolution of these towards a new generation of Prodrugs, and the evaluation of these in model systems for their therapeutic potential as anti-cancer agents in the clinic.