Microsatellite Instability-High Endometrial Cancers with MLH1 Promoter Hypermethylation Have Distinct Molecular and Clinical Profiles.

Beryl L Manning-Geist Ying L Liu Kelly A Devereaux Arnaud Da Cruz Paula Qin C Zhou Weining Ma Pier Selenica Ozge Ceyhan-Birsoy Lea A Moukarzel Timothy Hoang Sushmita Gordhandas Maria M Rubinstein Claire F Friedman Carol Aghajanian Nadeem R Abu-Rustum Zsofia K Stadler Jorge Sergio Reis-Filho Alexia E Iasonos Dmitriy Zamarin Lora H Ellenson Yulia Lakhman Diana L Mandelker Jorge S Reis-Filho

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

MLH1ph endometrial cancers likely constitute a distinct clinicopathologic entity compared with germline and somatic MMR-D ECs with potential treatment implications.

Keyphrases

endometrial cancer
dna methylation
gene expression
transcription factor
copy number
single molecule