Cardiac electrical instability in Erdheim-Chester disease: a case report.
Andrea UrbaniFilippo PensottiDiego CastiniSilvia MagnaniPasquale Simone SimeoliCorrado CampochiaroLorenzo DagnaAlberto M CappellettiCarlo SponzilliMarco GuazziPublished in: Oxford medical case reports (2022)
Erdheim-Chester disease (ECD) is a rare multisystemic disorder of non-Langerhans histiocytic cells with a pleomorphic clinical presentation. It affects bones, skin, central nervous system, pituitary gland, ocular tissue, kidneys and perirenal tissue and lungs. Cardiac involvement presents usually with pericardial effusion and right atrial masses, but rarely with conduction system infiltration and subsequent arrhythmic events. Following the discovery of mutations of activating signaling kinase proteins (BRAF, MEK, ALK), the therapeutic landscape has changed to a more precise targeted treatment. Currently vemurafenib is approved for patient with end-organ dysfunction and BRAF-V600E mutation and the prognosis has dramatically improved. Here we present a case of ECD with electrical instability as main clinically relevant manifestation of cardiac involvement.
Keyphrases
- left ventricular
- induced apoptosis
- small molecule
- signaling pathway
- oxidative stress
- atrial fibrillation
- magnetic resonance imaging
- single cell
- magnetic resonance
- cancer therapy
- cerebrospinal fluid
- endoplasmic reticulum stress
- left atrial
- pi k akt
- drug delivery
- mitral valve
- replacement therapy
- contrast enhanced
- catheter ablation