Association of angiotensin-converting enzyme (ACE) I/D variation with biochemical parameters and oxidative stress markers in systemic lupus erythematosus patients in west of Iran.
Amir KianiDaniel Elieh-Ali-KomiFariborz BahrehmandShayan MostafaeiAsad Vaisi-RayganiHosein BaniamerianFaranak AghazMaryam TanhapourEbrahim ShakibaZohreh RahimiTayebeh PourmotabbedPublished in: Molecular biology reports (2023)
Carriers of the DD genotype of ACE gene with higher serum concentrations of neopterin and MDA, and lower PON activity had a high risk to develop SLE, while ID genotype decreased the risk of disease development by 2.22 times compared to II genotype.
Keyphrases
- angiotensin converting enzyme
- angiotensin ii
- oxidative stress
- end stage renal disease
- newly diagnosed
- ejection fraction
- systemic lupus erythematosus
- prognostic factors
- dna damage
- copy number
- ischemia reperfusion injury
- disease activity
- cell proliferation
- transcription factor
- induced apoptosis
- endoplasmic reticulum stress
- cell cycle arrest