Valsartan reduced the vulnerability to atrial fibrillation by preventing action potential prolongation and conduction slowing in castrated male mice.
Yi-Lin SunPeng-Hui LiLing ShiWan-Zhen SuDe-Sheng LiGen-Long XueYue ZhaoChang-Zhu LiYing LiYang ZhouShang-Xuan LiYang ZhangYan-Jie LuZhen-Wei PanPublished in: Journal of cardiovascular electrophysiology (2018)
Valsartan reduced the susceptibility of AF in castrated mice, which may be related to the inhibition of action potential prolongation and improvement of atrial conduction impairment. This study indicates that valsartan may represent a useful agent for the prevention of AF pathogenesis in elderly male patients.
Keyphrases
- atrial fibrillation
- end stage renal disease
- left atrial
- oral anticoagulants
- chronic kidney disease
- ejection fraction
- newly diagnosed
- left atrial appendage
- heart failure
- climate change
- direct oral anticoagulants
- drug induced
- prognostic factors
- peritoneal dialysis
- human health
- metabolic syndrome
- middle aged
- insulin resistance
- risk assessment