A comprehensive review of m 6 A research in cervical cancer.
Jing HuShizhi WangXiuting LiPublished in: Epigenomics (2024)
Cervical cancer (CC) remains one of the most common malignancies among women worldwide, posing a serious threat to women's health. N6-methyladenosine (m 6 A) modification, as the most abundant type of RNA methylation modification, and has been found to play a crucial role in various cancers. Current research suggests a close association between RNA m 6 A modification and the occurrence and progression of CC, encompassing disruptions in m 6 A levels and its regulatory machinery. This review summarizes the current status of m 6 A modification research in CC, explores the mechanisms underlying m 6 A levels and regulators (methyltransferases, demethylases, reader proteins) in CC and examines the application of small-molecule inhibitors of m 6 A regulators in disease treatment. The findings provide new insights into the future treatment of CC.
Keyphrases
- small molecule
- current status
- transcription factor
- polycystic ovary syndrome
- public health
- healthcare
- risk assessment
- dna methylation
- type diabetes
- gene expression
- pregnancy outcomes
- genome wide
- young adults
- pregnant women
- insulin resistance
- skeletal muscle
- health information
- climate change
- protein protein
- breast cancer risk