Effect of Cognitive Reserve on the Association of Vascular Brain Injury With Cognition: Analysis of the PURE and CAHHM Studies.
Romella DurraniMatthias G FriedrichKarleen M SchulzePhilip AwadallaKumar BalasubramanianSandra E BlackPhilippe BroetDavid BusseuilDipika DesaiTrevor DummerAlexander DickJason HicksThomas IypeDavid KeltonAnish KirpalaniScott A LearJonathon LeipsicWei LiCheryl R McCrearyAlan R MoodyMichael D NoseworthyGrace ParragaPaul PoirierSumathy RangarajanDorota SzczesniakAndrzej SzubaJean-Claude TardifKoon TeoJennifer E VenaKatarzyna ZatonskaAnna ZimnyDouglas S LeeSalim YusufSonia S AnandEric E SmithPublished in: Neurology (2021)
Both vascular brain injury and markers of cognitive reserve are associated with cognition. However, the effects were independent such that the adverse effects of covert vascular brain injury were not attenuated by higher cognitive reserve. To improve cognitive brain health, interventions to both prevent cerebrovascular disease and promote positive lifestyles are needed.